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KMID : 0385920140250060771
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Journal of the Korean Society of Emergency Medicine
2014 Volume.25 No. 6 p.771 ~ p.774
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The Experience and Management of Two Cases of Metformin-associated Lactic
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Lee Hyeuk-Soo
Seong Choong-Sil
Kim Byung-Sun
Lee Woong-Ki
Choi Hye-Mi
Yoon Hyun-Ju
Kim Jeong-Gwan
Sun In-O
Lee Kwang-Young
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Abstract
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Metformin, a dimethylbiguanide, is an oral antihyperglycemicdrug used in treatment of type 2 diabetes mellitus. It has been reported that metformin may be associated withlactic acidosis in patients with clinical conditions such asrenal failure and heart failure. Metformin-associated lacticacidosis (MALA) is a rare, but serious complication with amortality rate of approximately 30~50%. Therefore, anaggressive treatment strategy including hemodialysis is recommendedfor these patients. Although continuous renalreplacement therapy (CRRT) has been administered inhemodynamically unstable patients with MALA, there arefew case reports describing the use of CRRT as a therapeuticmodality in Korea. Here, we describe the case historiesof two MALA patients who underwent treatment withCRRT.
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KEYWORD
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Metformin, Acidosis, Lactic, Renal replacement therapy
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